Secretory leucocyte protease inhibitor regulates bone metabolism and inflammation in experimental mouse periodontitis
Abstract Periodontitis is characterized by the activity of neutrophil elastase, a host defense factor that leads to the destruction of the epithelial barrier and bacterial invasion of the periodontal tissue. Secretory leukocyte protease inhibitors (SLPI), predominantly secreted by epithelial cells,...
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| Main Authors: | Karin Sasagawa, Hisanori Domon, Satoru Hirayama, Tomoki Maekawa, Toshihito Isono, Koichi Tabeta, Yutaka Terao |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-05-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-025-08197-3 |
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