Secretory leucocyte protease inhibitor regulates bone metabolism and inflammation in experimental mouse periodontitis

Abstract Periodontitis is characterized by the activity of neutrophil elastase, a host defense factor that leads to the destruction of the epithelial barrier and bacterial invasion of the periodontal tissue. Secretory leukocyte protease inhibitors (SLPI), predominantly secreted by epithelial cells,...

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Bibliographic Details
Main Authors: Karin Sasagawa, Hisanori Domon, Satoru Hirayama, Tomoki Maekawa, Toshihito Isono, Koichi Tabeta, Yutaka Terao
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08197-3
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