Matrix stiffness drives alterations in aldehyde metabolism, inducing DNA damage and transformation

Matrix stiffness drives alterations in aldehyde metabolism, inducing DNA damage and transformation

Summary Microenvironmental stiffness regulates fundamental aspects of cell behaviour, including proliferation, differentiation and metabolism, many of which are implicated in cancer initiation and progression. In the mammary gland, extracellular matrix (ECM) stiffness, associated with high mammograp...

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Main Authors: Matthew Jones, Hannah Percival, Alis Hales, Amber Wood, Heyuan Sun, Fabianna Tennant, Eleanor Broadberry, Eldhose Skaria, Harry Barnes, Egor Zindy, Craig Lawless, Charles Streuli, Joe Swift, Keith Brennan, Andrew P. Gilmore
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-12880-0
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https://doi.org/10.1038/s41598-025-12880-0

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