Crosstalk of injured podocytes with parietal epithelial cells through Wnt4/β-Catenin signaling

Crosstalk of injured podocytes with parietal epithelial cells through Wnt4/β-Catenin signaling

Abstract Focal segmental glomerular sclerosis (FSGS) is considered an irreversible lesion in kidney disease. Here, we investigated the role of the wnt4/β-Catenin signaling pathway in FSGS lesion formation and the crosstalk between PECs and podocytes in a transgenic FSGS rat model and human primary F...

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Bibliographic Details
Main Authors: Eike Schwartze, Eva Pfister, Nicole Endlich, Tim Endlich, Kerstin Amann, Maike Büttner-Herold, Jeff Pippin, Stuart J. Shankland, Christoph Daniel
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
Subjects:
Podocyte
Injury
Parietal epithelial cell
Wnt-pathway
Crosstalk
Online Access:https://doi.org/10.1038/s41598-025-04092-3
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https://doi.org/10.1038/s41598-025-04092-3

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