In vitro and preclinical evaluation of the antifungal activity of 6-methoxy-1 H-indole-2-carboxylic acid produced by Bacillus toyonensis strain OQ071612 formulated as nanosponge hydrogel

In vitro and preclinical evaluation of the antifungal activity of 6-methoxy-1 H-indole-2-carboxylic acid produced by Bacillus toyonensis strain OQ071612 formulated as nanosponge hydrogel

Abstract Background In a previous study, 6-methoxy-1 H-indole-2-carboxylic acid (MICA) was isolated from the culture broth of Bacillus toyonensis strain OQ071612 soil isolate in our laboratory, and it demonstrated promising antifungal activities. The current study was designed to create a nanosponge...

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Bibliographic Details
Main Authors: Sayed E. El-Sayed, Neveen A. Abdelaziz, Ghadir S. El-Housseiny, Khaled M. Aboshanab
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Microbial Cell Factories
Subjects:
Antifungal
Nanosponges
Hydrogel
Bacillus toyonensis
Box Behnken design
Online Access:https://doi.org/10.1186/s12934-025-02688-y
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https://doi.org/10.1186/s12934-025-02688-y

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