PGRN as an emerging regulator of lipid metabolism in neurodegenerative diseases

Abstract Dysregulated lipid metabolism in microglia represents a hallmark of neuroinflammation and is often observed in a variety of neurodegenerative diseases. The exact molecular mechanisms underlying the induction of altered lipid homeostasis and how it contributes to neurodegeneration remain to...

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Bibliographic Details
Main Authors: Yiyue Shi, Wenyu Hou, Bei Li, Caihong Zhu
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08272-9
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