Glucocorticoids trigger muscle-liver crosstalk to attenuate acute liver injury and promote liver regeneration via the FGF6-FGFBP1 axis

Glucocorticoids trigger muscle-liver crosstalk to attenuate acute liver injury and promote liver regeneration via the FGF6-FGFBP1 axis

Abstract Background Acute liver injury (ALI) requires rapid hepatic regeneration to avert fatal liver failure. As key mechanisms, systemic metabolic remodeling and inter-organ crosstalk are critical for this regenerative process. Skeletal muscle, as a major metabolic organ system, undergoes signific...

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Main Authors: Yue-Jie Xu, Cai-Zhi Liu, Ying Chen, Lan-Xin Li, Bo Xu, Ling-Xin You, Mei-Yao Meng, Xin Li, Hong Zhang, Qiu-Rong Ding, Rong Zhang, Xin-Ran Ma, Xiao-Hua Chen, Cheng Hu
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Military Medical Research
Subjects:
Acute liver injury (ALI)
Liver regeneration
Skeletal muscle
Fibroblast growth factor 6 (FGF6)
Fibroblast growth factor binding protein 1 (FGFBP1)
Online Access:https://doi.org/10.1186/s40779-025-00618-y
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https://doi.org/10.1186/s40779-025-00618-y

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