Enhancing thymic function improves T-cell reconstitution and immune responses in aged mice.

Enhancing thymic function improves T-cell reconstitution and immune responses in aged mice.

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Age-related thymic involution leads to diminished output of naïve T-cells. While this process is suggested to increase the risk of disease severity in the elderly following infection, direct evidence is lacking. We developed two mouse models that allow us to experimentally prevent or reverse thymic...

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Main Authors: Abigail Morales-Sánchez, Marieke Lavaert, Melanie S Vacchio, Gustavo Ulises Martinez-Ruiz, Daniel Egbase, Yongge Zhao, Ross Lake, Masaki Ishikawa, Fatima Zohra Braikia, Dragana Jankovic, Ranjan Sen, Rémy Bosselut, Avinash Bhandoola, Jennifer E Cowan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-07-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3003283
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https://doi.org/10.1371/journal.pbio.3003283

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