Energy landscape of a Kv channel revealed by temperature steps while perturbing its electromechanical coupling

Abstract Voltage-dependent potassium channels (Kv) play a crucial role in membrane repolarization during action potentials. They undergo voltage-dependent structural conformational transitions according to their distribution across their energy landscape. Understanding these transitions helps us com...

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Bibliographic Details
Main Authors: Bernardo I. Pinto-Anwandter, Carlos A. Z. Bassetto, Ramon Latorre, Francisco Bezanilla
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58443-9
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