Altered purinergic P2X7 and A2B receptors signaling limits macrophage-mediated host defense in schistosomiasis

Altered purinergic P2X7 and A2B receptors signaling limits macrophage-mediated host defense in schistosomiasis

Background: The occurrence of co-infections during schistosomiasis, a neglected tropical disease, with other parasites have been reported suggesting an impaired host immune defense. Macrophage purinergic P2X7 receptor (P2X7R) plays an important role against intracellular pathogens. Therefore, we inv...

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Main Authors: Maria Luiza Thorstenberg, Monique Daiane Andrade Martins, Nathália Ferreira Oliveira, Matheus Macedo L.V. Monteiro, Gustavo R.C. Santos, Henrique M. Gualberto Pereira, Luiz Eduardo Baggio Savio, Robson Coutinho-Silva, Claudia Lucia Martins Silva
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Biomedical Journal
Subjects:
Macrophages
Schistosomiasis
Host defense
Adenosine receptor
P2X7 receptor
Leishmaniasis
Online Access:http://www.sciencedirect.com/science/article/pii/S2319417024000167
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