Lipid nephrotoxicity mediated by HIF-1α activation accelerates tubular injury in diabetic nephropathy

Lipid nephrotoxicity mediated by HIF-1α activation accelerates tubular injury in diabetic nephropathy

This study is intended to explore the effect of hypoxia-inducible factor-1α (HIF-1α) activation on lipid accumulation in the diabetic kidney. A type 1 diabetic rat model was established by STZ intraperitoneal injection. Cobalt chloride (CoCl2) and YC-1 were used as the HIF-1α activator and antagonis...

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Bibliographic Details
Main Authors: Zebo Hu, Qianwen Zhu, Ying Wang, Xue Deng, Hui Yang, Mingjun Zhou, Jiyuan Zhang, Hao Wang, Haosen Wang, Lin Wang, Cui Zhang, Shu Li
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Renal Failure
Subjects:
Diabetic nephropathy
HIF-1α
YC-1
lipid accumulation
tubules
HK-2
Online Access:https://www.tandfonline.com/doi/10.1080/0886022X.2024.2347446
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https://www.tandfonline.com/doi/10.1080/0886022X.2024.2347446

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