Dynamic mechanical stimulation of alveolar epithelial-fibroblast models using the Flexcell tension system to study of lung disease mechanisms

Dynamic mechanical stimulation of alveolar epithelial-fibroblast models using the Flexcell tension system to study of lung disease mechanisms

Mechanical strain plays a significant role in lung pathophysiology. Current two-dimensional (2D) in vitro models fail to capture the lung's dynamic mechanical environment. We developed mechanically strained 2D and more complex three-dimensional (3D) alveolar epithelial-fibroblast co-cultures an...

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Bibliographic Details
Main Authors: Safiya Al Yazeedi, Tony Ju Feng Guo, Joban Sohd, Filsan Ahmed Abokor, Janaeya Zuri Baher, Logan Yee, Chung Cheung, Don D. Sin, Emmanuel Twumasi Osei
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Medicine
Subjects:
in vitro models
mechanical model
alveolar 3D epithelial-fibroblast model
Flexcell
multicellular 3D co-culture and organoid models
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2025.1552803/full
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https://www.frontiersin.org/articles/10.3389/fmed.2025.1552803/full

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