T cells' immunological synapses induce polarization of brain astrocytes in vivo and in vitro: a novel astrocyte response mechanism to cellular injury.

T cells' immunological synapses induce polarization of brain astrocytes in vivo and in vitro: a novel astrocyte response mechanism to cellular injury.

<h4>Background</h4>Astrocytes usually respond to trauma, stroke, or neurodegeneration by undergoing cellular hypertrophy, yet, their response to a specific immune attack by T cells is poorly understood. Effector T cells establish specific contacts with target cells, known as immunologica...

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Main Authors: Carlos Barcia, Nicholas S R Sanderson, Robert J Barrett, Kolja Wawrowsky, Kurt M Kroeger, Mariana Puntel, Chunyan Liu, Maria G Castro, Pedro R Lowenstein
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-08-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0002977&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0002977&type=printable

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