Distribution of copy number alterations and impact of chromosome arm call thresholds for meningioma

Abstract Chromosome-arm copy number alterations (CNAs) are an important component of cancer molecular classifiers. CNAs are often translated into binary chromosome arm calls (arm gain/loss) using an arm call threshold before integration into classification schemes. However, substantial variability e...

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Bibliographic Details
Main Authors: Ruchit V. Patel, Hia S. Ghosh, David M. Meredith, Scott Ryall, Elizabeth B. Claus, Rameen Beroukhim, Azra H. Ligon, Sandro Santagata, Wenya Linda Bi
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60734-0
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