Bunyaviral Cap-Snatching Endonuclease Activity and Inhibition with Baloxavir-like Inhibitors in the Context of Full-Length L Proteins

Bunyaviral Cap-Snatching Endonuclease Activity and Inhibition with Baloxavir-like Inhibitors in the Context of Full-Length L Proteins

The <i>Bunyavirales</i> order includes a range of zoonotic viruses, which can cause severe disease in humans. The viral replication machinery is a logical target for the development of direct-acting antivirals. Inhibition of the cap-snatching endonuclease activity of related influenza vi...

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Bibliographic Details
Main Authors: Arlo J. Loutan, Baiuyan Yang, Gabrielle Connolly, Adam Montoya, Robert J. Smiley, Arnab K. Chatterjee, Matthias Götte
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Viruses
Subjects:
bunyaviruses
cap-snatching
nuclease activity
viral RNA-dependent RNA polymerase
RdRp
baloxavir
Online Access:https://www.mdpi.com/1999-4915/17/3/420
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