Exogenous estrogen enhances T cell activation in male primates

Exogenous estrogen enhances T cell activation in male primates

Summary: Estrogen influences T cell development and enhances infection resistance in females, but its immunological effects during gender-affirming hormone therapy (GAHT) remain poorly understood. Here, we characterize immune adaptations in male rhesus macaques (RMs) treated with 17β-estradiol (E2)...

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Main Authors: Patricia A. Hahn, Joan Escrivà-Font, Eric S. Alexander, Kimberly Weisgrau, Tianling Ou, Wenhui He, Daniel O’Hagan, Laura C.F. Da Silva, Noah J. Gurley, Li Lin, Michael D. Cameron, Eva Rakasz, Michael Farzan, Joe R. Kurian, Saverio Capuano, III, Camila R. Consiglio, Mauricio A. Martins
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Cell Reports
Subjects:
CP: Immunology
CP: Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725009416
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http://www.sciencedirect.com/science/article/pii/S2211124725009416

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