Endometrial tumorigenesis involves epigenetic plasticity demarcating non-coding somatic mutations and 3D-genome alterations

Endometrial tumorigenesis involves epigenetic plasticity demarcating non-coding somatic mutations and 3D-genome alterations

Abstract Background The incidence and mortality of endometrial cancer (EC) is on the rise. Eighty-five percent of ECs depend on estrogen receptor alpha (ERα) for proliferation, but little is known about its transcriptional regulation in these tumors. Results We generate epigenomics, transcriptomics,...

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Main Authors: Sebastian Gregoricchio, Aleksandar Kojic, Marlous Hoogstraat, Karianne Schuurman, Suzan Stelloo, Tesa M. Severson, Tracy A. O’Mara, Marjolein Droog, Abhishek A. Singh, Dylan M. Glubb, Lodewyk F. A. Wessels, Michiel Vermeulen, Flora E. van Leeuwen, Wilbert Zwart
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Genome Biology
Subjects:
Endometrial cancer
Estrogen receptor
Epigenetic plasticity in tumor development
Gene regulation
3D genome organization
Non-coding somatic mutations
Online Access:https://doi.org/10.1186/s13059-025-03596-5
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https://doi.org/10.1186/s13059-025-03596-5

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