Effect of urolithin A on intracellular survival of Mycobacterium tuberculosis by regulating AKT-FOXO1-mediated autophagy

ABSTRACT Tuberculosis (TB), resulting from Mycobacterium tuberculosis (Mtb), is one of the leading causes of morbidity and mortality in humans worldwide. Host-directed therapy (HDT) is a novel approach for treating TB, particularly those with drug resistance. Urolithin A (UroA) produced through bioc...

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Main Authors: Jing Bi, Li Song, Qinglong Guo, Xi Chen, Yaqi Gong, Haojia Wu, Fan Zhang, Jingbin Wang, Guoliang Zhang
Format: Article
Language:English
Published: American Society for Microbiology 2025-05-01
Series:mSphere
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Online Access:https://journals.asm.org/doi/10.1128/msphere.00061-25
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