Bat SARS-Like WIV1 coronavirus uses the ACE2 of multiple animal species as receptor and evades IFITM3 restriction via TMPRSS2 activation of membrane fusion

Bat SARS-Like WIV1 coronavirus uses the ACE2 of multiple animal species as receptor and evades IFITM3 restriction via TMPRSS2 activation of membrane fusion

Diverse SARS-like coronaviruses (SL-CoVs) have been identified from bats and other animal species. Like SARS-CoV, some bat SL-CoVs, such as WIV1, also use angiotensin converting enzyme 2 (ACE2) from human and bat as entry receptor. However, whether these viruses can also use the ACE2 of other animal...

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Bibliographic Details
Main Authors: Mei Zheng, Xuesen Zhao, Shuangli Zheng, Danying Chen, Pengcheng Du, Xinglin Li, Dong Jiang, Ju-Tao Guo, Hui Zeng, Hanxin Lin
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Emerging Microbes and Infections
Subjects:
SARS-like coronavirus WIV1
ACE2 receptor
viral entry
IFITM
TMPRSS2
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2020.1787797
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https://www.tandfonline.com/doi/10.1080/22221751.2020.1787797

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