Malaria-derived hemozoin skews dendritic cell responses to bacterial infections by reducing interferon gene-transcription by SWI/SNF-NuRD

Malaria-derived hemozoin skews dendritic cell responses to bacterial infections by reducing interferon gene-transcription by SWI/SNF-NuRD

Summary: Hemozoin (HZ), the malaria pigment, is associated with the disease when released during the pro-inflammatory blood stage and co-infections with bacteria lead to a more severe disease progression. The underlying mechanisms are poorly understood and, here, we show that the impact of co-exposu...

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Main Authors: Gintare Lasaviciute, Kanwal Tariq, Anaswara Sugathan, Jaclyn Quin, Mareike Polenkowski, Ioana Bujila, Oleksii Skorokhod, Marita Troye-Blomberg, Eva Sverremark-Ekström, Ann-Kristin Östlund Farrants
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:iScience
Subjects:
Immune response
Molecular mechanism of gene regulation
arasitology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225013070
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