A brain microvasculature endothelial cell‐specific viral vector with the potential to treat neurovascular and neurological diseases

A brain microvasculature endothelial cell‐specific viral vector with the potential to treat neurovascular and neurological diseases

Abstract Gene therapy critically relies on vectors that combine high transduction efficiency with a high degree of target specificity and that can be administered through a safe intravenous route. The lack of suitable vectors, especially for gene therapy of brain disorders, represents a major obstac...

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Main Authors: Jakob Körbelin, Godwin Dogbevia, Stefan Michelfelder, Dirk A Ridder, Agnes Hunger, Jan Wenzel, Henning Seismann, Melanie Lampe, Jacqueline Bannach, Manolis Pasparakis, Jürgen A Kleinschmidt, Markus Schwaninger, Martin Trepel
Format: Article
Language:English
Published: Springer Nature 2016-04-01
Series:EMBO Molecular Medicine
Subjects:
adeno‐associated virus
brain microvascular endothelial cells
gene therapy
neurovascular diseases
Online Access:https://doi.org/10.15252/emmm.201506078
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https://doi.org/10.15252/emmm.201506078

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