Alcohol induces α2‐6sialo mucin O‐glycans that kill U937 macrophages mediated by sialic acid‐binding immunoglobulin‐like lectin 7 (Siglec 7)
Alcohol misuse increases infections and cancer fatalities, but mechanisms underlying its toxicity are ill‐defined. We show that alcohol treatment of human tracheobronchial epithelial cells leads to inactivation of giantin‐mediated Golgi targeting of glycosylation enzymes. Loss of core 2 N‐acetylgluc...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
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| Series: | FEBS Open Bio |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/2211-5463.13919 |
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