Integrative multi-omics analysis of IFNγ-induced macrophages and atherosclerotic plaques reveals macrophage-dependent STAT1-driven transcription in atherosclerosis

Integrative multi-omics analysis of IFNγ-induced macrophages and atherosclerotic plaques reveals macrophage-dependent STAT1-driven transcription in atherosclerosis

Atherosclerosis is a chronic inflammatory disease of blood vessels, characterized by atherosclerotic lesions in large- and medium-sized arteries. IFNγ is a crucial mediator of atherosclerosis through activation of signal transducer and activator of transcription (STAT)1. Macrophages (MØ), in differe...

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Bibliographic Details
Main Authors: Mahdi Eskandarian Boroujeni, Natalia Lopacinska, Aleksandra Antonczyk, Katarzyna Kluzek, Joanna Wesoly, Hans A. R. Bluyssen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
atherosclerosis
IFNγ signaling
STAT1
multi-omics integration
macrophages
single cell RNA-seq
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1590953/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1590953/full

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