Hemozoin induces malaria via activation of DNA damage, p38 MAPK and neurodegenerative pathways in a human iPSC-derived neuronal model of cerebral malaria

Hemozoin induces malaria via activation of DNA damage, p38 MAPK and neurodegenerative pathways in a human iPSC-derived neuronal model of cerebral malaria

Abstract Malaria caused by Plasmodium falciparum infection results in severe complications including cerebral malaria (CM), in which approximately 30% of patients end up with neurological sequelae. Sparse in vitro cell culture-based experimental models which recapitulate the molecular basis of CM in...

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Bibliographic Details
Main Authors: Abida Islam Pranty, Leon-Phillip Szepanowski, Wasco Wruck, Akua Afriyie Karikari, James Adjaye
Format: Article
Language:English
Published: Nature Portfolio 2024-10-01
Series:Scientific Reports
Subjects:
iPSCs
Neurons
Hemozoin
Cerebral malaria
Neuro-inflammation
DNA damage
Online Access:https://doi.org/10.1038/s41598-024-76259-3
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https://doi.org/10.1038/s41598-024-76259-3

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