Prognostic signature based on mitochondria- and angiogenesis-related genes associated with immune microenvironment of multiple myeloma
Introduction: Mitochondria and angiogenesis play key roles in multiple myeloma (MM) development, but their interrelated genes affecting MM prognosis are under-studied.Methods: We analyzed TCGA_MMRF and GSE4581 datasets to identify four genes – CCNB1, CDC25C, HSP90AA1, and PARP1 – that significantly...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Hematology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/16078454.2025.2456649 |
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| author | Dai Zhang Yu Xing Lu Liu Xiaoqing Zhang Cong Ma MengYao Xu Ruiqi Li HanJing Wei Yan Zhao Bingxin Xu Shuhao Mei |
| author_facet | Dai Zhang Yu Xing Lu Liu Xiaoqing Zhang Cong Ma MengYao Xu Ruiqi Li HanJing Wei Yan Zhao Bingxin Xu Shuhao Mei |
| author_sort | Dai Zhang |
| collection | DOAJ |
| description | Introduction: Mitochondria and angiogenesis play key roles in multiple myeloma (MM) development, but their interrelated genes affecting MM prognosis are under-studied.Methods: We analyzed TCGA_MMRF and GSE4581 datasets to identify four genes – CCNB1, CDC25C, HSP90AA1, and PARP1 – that significantly correlate with MM prognosis, with high expression indicating poor outcomes.Results: A prognostic signature based on these genes stratified patients into high- and low-risk groups, with the latter showing better survival. The signature was validated as an independent prognostic factor. Biological function analysis revealed differences in cell cycle processes between risk groups, and immune microenvironment analysis showed distinct immune cell infiltration patterns.Conclusion: This mitochondria- and angiogenesis-related prognostic signature could enhance MM prognosis assessment and offer new therapeutic insights. |
| format | Article |
| id | doaj-art-b5161d5ece6742e387ad3aa7a7651e31 |
| institution | Kabale University |
| issn | 1607-8454 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Hematology |
| spelling | doaj-art-b5161d5ece6742e387ad3aa7a7651e312025-01-28T10:24:03ZengTaylor & Francis GroupHematology1607-84542025-12-0130110.1080/16078454.2025.2456649Prognostic signature based on mitochondria- and angiogenesis-related genes associated with immune microenvironment of multiple myelomaDai Zhang0Yu Xing1Lu Liu2Xiaoqing Zhang3Cong Ma4MengYao Xu5Ruiqi Li6HanJing Wei7Yan Zhao8Bingxin Xu9Shuhao Mei10Department of Hematology, XuChang Central Hospital, XuChang, People’s Republic of ChinaDepartment of Hematology, XuChang Central Hospital, XuChang, People’s Republic of ChinaDepartment of Hematology, XuChang Central Hospital, XuChang, People’s Republic of ChinaDepartment of Hematology, XuChang Central Hospital, XuChang, People’s Republic of ChinaDepartment of Hematology, XuChang Central Hospital, XuChang, People’s Republic of ChinaDepartment of Hematology, XuChang Central Hospital, XuChang, People’s Republic of ChinaDepartment of Hematology, XuChang Central Hospital, XuChang, People’s Republic of ChinaResearch Center for Clinical Medical Sciences, XuChang Central Hospital, XuChang, People’s Republic of ChinaResearch Center for Clinical Medical Sciences, XuChang Central Hospital, XuChang, People’s Republic of ChinaResearch Center for Clinical Medical Sciences, XuChang Central Hospital, XuChang, People’s Republic of ChinaDepartment of Hematology, XuChang Central Hospital, XuChang, People’s Republic of ChinaIntroduction: Mitochondria and angiogenesis play key roles in multiple myeloma (MM) development, but their interrelated genes affecting MM prognosis are under-studied.Methods: We analyzed TCGA_MMRF and GSE4581 datasets to identify four genes – CCNB1, CDC25C, HSP90AA1, and PARP1 – that significantly correlate with MM prognosis, with high expression indicating poor outcomes.Results: A prognostic signature based on these genes stratified patients into high- and low-risk groups, with the latter showing better survival. The signature was validated as an independent prognostic factor. Biological function analysis revealed differences in cell cycle processes between risk groups, and immune microenvironment analysis showed distinct immune cell infiltration patterns.Conclusion: This mitochondria- and angiogenesis-related prognostic signature could enhance MM prognosis assessment and offer new therapeutic insights.https://www.tandfonline.com/doi/10.1080/16078454.2025.2456649Multiple myelomamitochondria- and angiogenesis-related genesprognostic signatureimmunotherapy |
| spellingShingle | Dai Zhang Yu Xing Lu Liu Xiaoqing Zhang Cong Ma MengYao Xu Ruiqi Li HanJing Wei Yan Zhao Bingxin Xu Shuhao Mei Prognostic signature based on mitochondria- and angiogenesis-related genes associated with immune microenvironment of multiple myeloma Hematology Multiple myeloma mitochondria- and angiogenesis-related genes prognostic signature immunotherapy |
| title | Prognostic signature based on mitochondria- and angiogenesis-related genes associated with immune microenvironment of multiple myeloma |
| title_full | Prognostic signature based on mitochondria- and angiogenesis-related genes associated with immune microenvironment of multiple myeloma |
| title_fullStr | Prognostic signature based on mitochondria- and angiogenesis-related genes associated with immune microenvironment of multiple myeloma |
| title_full_unstemmed | Prognostic signature based on mitochondria- and angiogenesis-related genes associated with immune microenvironment of multiple myeloma |
| title_short | Prognostic signature based on mitochondria- and angiogenesis-related genes associated with immune microenvironment of multiple myeloma |
| title_sort | prognostic signature based on mitochondria and angiogenesis related genes associated with immune microenvironment of multiple myeloma |
| topic | Multiple myeloma mitochondria- and angiogenesis-related genes prognostic signature immunotherapy |
| url | https://www.tandfonline.com/doi/10.1080/16078454.2025.2456649 |
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