Repurposing Dapagliflozin for Mitigation of the Kidney Injury Triggered by Cadmium in Rats: Role of Autophagy, Apoptosis, and the SIRT1/Nrf2/HO-1 Pathway

Repurposing Dapagliflozin for Mitigation of the Kidney Injury Triggered by Cadmium in Rats: Role of Autophagy, Apoptosis, and the SIRT1/Nrf2/HO-1 Pathway

<b>Background/Objectives:</b> The antioxidant/antiapoptotic features of dapagliflozin (DPG) have mediated its beneficial actions against several experimental models. However, no studies have been conducted to determine whether DPG mitigates the renal injury triggered by cadmium (Cd). Her...

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Bibliographic Details
Main Authors: Hany H. Arab, Musaad M. Althobaiti, Abdulaziz S. Alharthi, Emad O. Almalki, Saif S. Alsoubie, Jawad M. Qattan, Saeed A. Almalki, Ahmed M. Ashour, Ahmed H. Eid
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Pharmaceuticals
Subjects:
AMPK
autophagy
cadmium
dapagliflozin
nephrotoxicity
SIRT1
Online Access:https://www.mdpi.com/1424-8247/17/12/1690
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