Demystifying the cGAS-STING pathway: precision regulation in the tumor immune microenvironment

Demystifying the cGAS-STING pathway: precision regulation in the tumor immune microenvironment

Abstract The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway serves as an immune sentinel for cytosolic DNA, recognizing double-stranded DNA (dsDNA) derived from abnormally localized nuclear DNA or mitochondrial DNA (mtDNA), and plays a pivotal role in innate...

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Bibliographic Details
Main Authors: Qingyang Wang, Yang Yu, Jing Zhuang, Ruijuan Liu, Changgang Sun
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Molecular Cancer
Subjects:
cGAS-STING pathway
Tumor immune microenvironment
Immune cells
Agonists
Combination therapy
“Double-edged sword” effect
Online Access:https://doi.org/10.1186/s12943-025-02380-0
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https://doi.org/10.1186/s12943-025-02380-0

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