Activation of Silent Information Regulator 6 Signaling Attenuates Myocardial Fibrosis by Reducing TGFβ1-Smad2/3 Signaling in a Type 2 Diabetic Animal Model

Activation of Silent Information Regulator 6 Signaling Attenuates Myocardial Fibrosis by Reducing TGFβ1-Smad2/3 Signaling in a Type 2 Diabetic Animal Model

Abstract. Objective:. Long-term diabetes can result in ventricular hypertrophic remodeling, tissue fibrosis, myocardial metabolic defection, and eventually, heart failure. Silent information regulator 6 (SIRT6) exerts beneficial effects against cardiovascular diseases. This study is aimed to investi...

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Main Authors: Liming Yu, Jian Wang, Xue Dong, Yue Hu, Linyu Luo, Xiaodong Xue, Yang Wang, Tianyu Xu, Xiaoxia Fu
Format: Article
Language:English
Published: Wolters Kluwer Health/LWW 2022-03-01
Series:Cardiology Discovery
Online Access:http://journals.lww.com/10.1097/CD9.0000000000000031
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http://journals.lww.com/10.1097/CD9.0000000000000031

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