Fungal Exposure and Low Levels of IL-10 in Patients with Sarcoidosis
Background and Objectives. Sarcoidosis is an inflammatory disease with increased levels of inflammatory cytokines. Previous studies have shown a relation between the degree of granuloma infiltration and serum cytokine levels, except for interleukin- (IL-) 10. The aim of the study was to further inve...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Pulmonary Medicine |
| Online Access: | http://dx.doi.org/10.1155/2014/164565 |
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| author | Marjeta Terčelj Sanja Stopinšek Alojz Ihan Barbara Salobir Saša Simčič Ragnar Rylander |
| author_facet | Marjeta Terčelj Sanja Stopinšek Alojz Ihan Barbara Salobir Saša Simčič Ragnar Rylander |
| author_sort | Marjeta Terčelj |
| collection | DOAJ |
| description | Background and Objectives. Sarcoidosis is an inflammatory disease with increased levels of inflammatory cytokines. Previous studies have shown a relation between the degree of granuloma infiltration and serum cytokine levels, except for interleukin- (IL-) 10. The aim of the study was to further investigate the serum levels of IL-10 in patients with sarcoidosis and relate them to fungal exposure in terms of the amount of fungi in the air of their homes and β-glucan in bronchoalveolar lavage (BAL) fluid. Methods. Patients with sarcoidosis (n=71) and healthy controls (n=27) were enrolled. IL-10 was determined in serum. BAL was performed and the amount of β-glucan was measured. Domestic exposure to fungi was determined by measuring airborne β-N-acetylhexosaminidase (NAHA) in the bedrooms. Results. At high levels of fungal exposure (domestic fungal exposure and β-glucan in BAL), serum IL-10 values were lower than at low and intermediate exposure levels. Conclusion. The low serum IL-10 values at high fungal exposure suggest that fungal cell wall agents play a role in granuloma formation in sarcoidosis by inhibiting the secretion of the anti-inflammatory cytokine IL-10. |
| format | Article |
| id | doaj-art-b4c3d419bc1740959d9eb4085f765c39 |
| institution | Kabale University |
| issn | 2090-1836 2090-1844 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pulmonary Medicine |
| spelling | doaj-art-b4c3d419bc1740959d9eb4085f765c392025-02-03T05:58:08ZengWileyPulmonary Medicine2090-18362090-18442014-01-01201410.1155/2014/164565164565Fungal Exposure and Low Levels of IL-10 in Patients with SarcoidosisMarjeta Terčelj0Sanja Stopinšek1Alojz Ihan2Barbara Salobir3Saša Simčič4Ragnar Rylander5Department of Respiratory and Allergic Diseases, The University Medical Centre, Ljubljana, SloveniaInstitute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, SloveniaInstitute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, SloveniaDepartment of Respiratory and Allergic Diseases, The University Medical Centre, Ljubljana, SloveniaInstitute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, SloveniaBiofact Environmental Health Research Center, Björkåsvägen 21, 44391 Lerum, SwedenBackground and Objectives. Sarcoidosis is an inflammatory disease with increased levels of inflammatory cytokines. Previous studies have shown a relation between the degree of granuloma infiltration and serum cytokine levels, except for interleukin- (IL-) 10. The aim of the study was to further investigate the serum levels of IL-10 in patients with sarcoidosis and relate them to fungal exposure in terms of the amount of fungi in the air of their homes and β-glucan in bronchoalveolar lavage (BAL) fluid. Methods. Patients with sarcoidosis (n=71) and healthy controls (n=27) were enrolled. IL-10 was determined in serum. BAL was performed and the amount of β-glucan was measured. Domestic exposure to fungi was determined by measuring airborne β-N-acetylhexosaminidase (NAHA) in the bedrooms. Results. At high levels of fungal exposure (domestic fungal exposure and β-glucan in BAL), serum IL-10 values were lower than at low and intermediate exposure levels. Conclusion. The low serum IL-10 values at high fungal exposure suggest that fungal cell wall agents play a role in granuloma formation in sarcoidosis by inhibiting the secretion of the anti-inflammatory cytokine IL-10.http://dx.doi.org/10.1155/2014/164565 |
| spellingShingle | Marjeta Terčelj Sanja Stopinšek Alojz Ihan Barbara Salobir Saša Simčič Ragnar Rylander Fungal Exposure and Low Levels of IL-10 in Patients with Sarcoidosis Pulmonary Medicine |
| title | Fungal Exposure and Low Levels of IL-10 in Patients with Sarcoidosis |
| title_full | Fungal Exposure and Low Levels of IL-10 in Patients with Sarcoidosis |
| title_fullStr | Fungal Exposure and Low Levels of IL-10 in Patients with Sarcoidosis |
| title_full_unstemmed | Fungal Exposure and Low Levels of IL-10 in Patients with Sarcoidosis |
| title_short | Fungal Exposure and Low Levels of IL-10 in Patients with Sarcoidosis |
| title_sort | fungal exposure and low levels of il 10 in patients with sarcoidosis |
| url | http://dx.doi.org/10.1155/2014/164565 |
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