Chemical combinations elucidate pathway interactions and regulation relevant to Hepatitis C replication

Chemical combinations elucidate pathway interactions and regulation relevant to Hepatitis C replication

Abstract The search for effective Hepatitis C antiviral therapies has recently focused on host sterol metabolism and protein prenylation pathways that indirectly affect viral replication. However, inhibition of the sterol pathway with statin drugs has not yielded consistent results in patients. Here...

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Bibliographic Details
Main Authors: Christopher M Owens, Christina Mawhinney, Jill M Grenier, Ralf Altmeyer, Margaret S Lee, Alexis A Borisy, Joseph Lehár, Lisa M Johansen
Format: Article
Language:English
Published: Springer Nature 2010-06-01
Series:Molecular Systems Biology
Subjects:
chemical genetics
combinations and synergy
hepatitis C
replicon
sterol biosynthesis
Online Access:https://doi.org/10.1038/msb.2010.32
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https://doi.org/10.1038/msb.2010.32

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