Altered Neural Activity in the Mesoaccumbens Pathway Underlies Impaired Social Reward Processing in Shank3‐Deficient Rats

Altered Neural Activity in the Mesoaccumbens Pathway Underlies Impaired Social Reward Processing in Shank3‐Deficient Rats

Abstract Social behaviors are crucial for human connection and belonging, often impacted by conditions like Autism Spectrum Disorder (ASD). The mesoaccumbens pathway (ventral tegmental area (VTA) to the nucleus accumbense (NAc)) plays a pivotal role in social behavior and is implicated in ASD. Howev...

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Bibliographic Details
Main Authors: Marie Barbier, Keerthi Thirtamara Rajamani, Shai Netser, Shlomo Wagner, Hala Harony‐Nicolas
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:Advanced Science
Subjects:
autism spectrum disorder
dopamine
Phelan‐McDermid syndrome
reward
Shank3
social interaction
Online Access:https://doi.org/10.1002/advs.202414813
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https://doi.org/10.1002/advs.202414813

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