Diversification of <i>Pseudomonas aeruginosa</i> After Inhaled Tobramycin Therapy of Cystic Fibrosis Patients: Genotypic and Phenotypic Characteristics of Paired Pre- and Post-Treatment Isolates

Diversification of <i>Pseudomonas aeruginosa</i> After Inhaled Tobramycin Therapy of Cystic Fibrosis Patients: Genotypic and Phenotypic Characteristics of Paired Pre- and Post-Treatment Isolates

This study examines the impact of inhaled tobramycin therapy on the within-host changes in <i>P. aeruginosa</i> strains isolated from Bulgarian patients with CF prior to and post treatment. Genotypic comparison by RAPD-PCR indicated that most of the pre-treatment isolates had a high simi...

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Main Authors: Dayana Borisova, Tanya Strateva, Svetoslav G. Dimov, Borjana Atanassova, Tsvetelina Paunova-Krasteva, Tanya Topouzova-Hristova, Svetla T. Danova, Rositsa Tropcheva, Stoyanka Stoitsova
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Microorganisms
Subjects:
<i>Pseudomonas aeruginosa</i>
paired cystic fibrosis pre- and post- treatment isolates
inhaled tobramycin treatment
RAPD-PCR
growth
biofilm
Online Access:https://www.mdpi.com/2076-2607/13/4/730
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