Enhancement of systemic and lung-localized CD4<sup>+</sup> T-cell immune responses by truncation of NS1 protein of a seasonal live influenza vaccine strain

Enhancement of systemic and lung-localized CD4<sup>+</sup> T-cell immune responses by truncation of NS1 protein of a seasonal live influenza vaccine strain

Introduction. There is a large variety of licensed influenza vaccines worldwide, but their common limitation is rather narrow specificity and inability to protect against antigenic-drift variants of influenza virus. Therefore, optimization of immunogenic and cross-protective properties of licensed i...

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Main Authors: Polina I. Prokopenko, Ekaterina A. Stepanova, Victoria A. Matyushenko, Alexandra Ya. Rak, Anna K. Chistyakova, Arina D. Kostromitina, Tatyana S. Kotomina, Igor V. Kudryavtsev, Artem A. Rubinstein, Alexey S. Komlev, Larisa G. Rudenko, Irina N. Isakova-Sivak
Format: Article
Language:Russian
Published: Central Research Institute for Epidemiology 2024-11-01
Series:Журнал микробиологии, эпидемиологии и иммунобиологии
Subjects:
influenza virus
live attenuated influenza vaccine
ns1 protein
memory t cells
tissue-resident memory t cells
cd4+ т cells, cd8+ т cells
Online Access:https://microbiol.crie.ru/jour/article/viewFile/18682/1518
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