Low Citrate Synthase Activity Is Associated with Glucose Intolerance and Lipotoxicity

Low Citrate Synthase Activity Is Associated with Glucose Intolerance and Lipotoxicity

Citrate synthase (CS) is a key mitochondrial enzyme. The aim of this study was to test the hypothesis that low CS activity impairs the metabolic health of mice fed a high fat diet (HFD) and promotes palmitate-induced lipotoxicity in muscle cells. C57BL/6J (B6) mice and congenic B6.A-(rs3676616-D10Ut...

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Main Authors: Yosra Alhindi, Lobke M. Vaanholt, Mustafah Al-Tarrah, Stuart R. Gray, John R. Speakman, Catherine Hambly, Bader S. Alanazi, Brendan M. Gabriel, Arimantas Lionikas, Aivaras Ratkevicius
Format: Article
Language:English
Published: Wiley 2019-01-01
Series:Journal of Nutrition and Metabolism
Online Access:http://dx.doi.org/10.1155/2019/8594825
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