Mesenchymal stromal cells promote the formation of lung cancer organoids via Kindlin-2

Mesenchymal stromal cells promote the formation of lung cancer organoids via Kindlin-2

Abstract Background Patient-derived lung cancer organoids (PD-LCOs) demonstrate exceptional potential in preclinical testing and serve as a promising model for the multimodal management of lung cancer. However, certain lung cancer cells derived from patients exhibit limited capacity to generate orga...

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Main Authors: Zhilin Sui, Xianxian Wu, Jiaxin Wang, ShihJye Tan, Chao Zhao, Zhentao Yu, Chuanyue Wu, Xiaoxiao Wang, Ling Guo
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Stem Cell Research & Therapy
Subjects:
Lung cancer organoids (LCOs)
Mesenchymal stromal cells (MSCs)
Fibroblast
Kindlin-2
Tumor microenvironment (TME)
Online Access:https://doi.org/10.1186/s13287-024-04128-x
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https://doi.org/10.1186/s13287-024-04128-x

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