Differential replication, pathology, and immune response of clade IIb mpox virus in C57BL/6 and BALB/c mice

Differential replication, pathology, and immune response of clade IIb mpox virus in C57BL/6 and BALB/c mice

We have previously established a clade IIb mpox virus (MPXV) pathogenic BALB/c mouse model for developing mpox countermeasures. Here, we comprehensively investigated the susceptibility of BALB/c and C57BL/6 mice to MPXV and found that Clade IIb MPXV was capable of rapid replication in the lungs of b...

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Bibliographic Details
Main Authors: Meimei Duan, Xiangmei Zhang, Xian Tang, Zhuohuan Li, Wenqi Huang, Qi Chen, Mingxia Zhang, Lin Cheng, Zheng Zhang
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Emerging Microbes and Infections
Subjects:
MPXV
clade IIb
mouse model
BALB/c
C57BL/6
pathological feature
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2025.2479043
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https://www.tandfonline.com/doi/10.1080/22221751.2025.2479043

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