Polyphenol-based self-assembled nanoparticles treating uveitis by inflammation-oxidative stress suppression

Polyphenol-based self-assembled nanoparticles treating uveitis by inflammation-oxidative stress suppression

The breakdown of the blood-retinal barrier (BRB), which induces vascular leakage, represents a critical pathological hallmark underlying severe vision loss in uveitis. The inflammatory response triggers phenotypic alterations in microglia, driving excessive reactive oxygen species (ROS) production a...

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Bibliographic Details
Main Authors: Haoxiang Chen, Qiwei Yang, Minghao Li, Mengyao Ren, Shuliang Liu, Guangqi An, Yaxin Ren, Pei Liu, Liping Du, Xinzhi Sun, Xuemin Jin
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Materials Today Bio
Subjects:
Uveitis
Blood-retinal barrier
Self-assembled nanoparticles
Synergetic therapy
Microglia polarization
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006425006222
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