Cryoablation-induced neutrophil Ca2+ elevation and NET formation exacerbate immune escape in colorectal cancer liver metastasis

Cryoablation-induced neutrophil Ca2+ elevation and NET formation exacerbate immune escape in colorectal cancer liver metastasis

Abstract Background Liver metastasis poses a significant barrier to effective immunotherapy in patients with colorectal cancer. Cryoablation has emerged as a vital supplementary therapeutic approach for these patients. However, its impact on the tumor microenvironment following the ablation of liver...

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Main Authors: Hongtong Tan, Yiquan Jiang, Lujun Shen, Gulijiayina Nuerhashi, Chunyong Wen, Ling Gu, Yujia Wang, Han Qi, Fei Cao, Tao Huang, Ying Liu, Weining Xie, Wuguo Deng, Weijun Fan
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Cryoablation
Neutrophils
Liver metastasis
Immunotherapy
Online Access:https://doi.org/10.1186/s13046-024-03244-z
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https://doi.org/10.1186/s13046-024-03244-z

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