Discovery of novel SND1 inhibitors by in silico–based molecular docking and dynamics simulation methods for managing hepatocellular carcinoma

Discovery of novel SND1 inhibitors by in silico–based molecular docking and dynamics simulation methods for managing hepatocellular carcinoma

Abstract Hepatocellular carcinoma (HCC) is one of the life–threatening cancers in the current decade. Earlier reports suggest that protein arginine methyl transferase 5 (PRMT5) is also linked with HCC, and the symmetrically dimethylated arginine marks created by PRMT5 are read by the Staphylococcal...

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Bibliographic Details
Main Authors: Yuvaraj Ravikumar, Sirajunnisa Abdul Razack, Shilpa Sivashankar, Sirichai Srichairatanakool, Pimpisid Koonyosying, Somdet Srichairatanakool
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Hepatocellular carcinoma
SND1 inhibitor
In silico virtual screening
Molecular dynamics
Simulation
Pharmacokinetic properties
Online Access:https://doi.org/10.1038/s41598-025-14878-0
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https://doi.org/10.1038/s41598-025-14878-0

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