In artemisinin-resistant falciparum malaria parasites, mitochondrial metabolic pathways are essential for survival but not those of apicoplast

In artemisinin-resistant falciparum malaria parasites, mitochondrial metabolic pathways are essential for survival but not those of apicoplast

Emergence and spread of parasite resistance to artemisinins, the first-line antimalarial therapy, threaten the malaria eradication policy. To identify therapeutic targets to eliminate artemisinin-resistant parasites, the functioning of the apicoplast and the mitochondrion was studied, focusing on th...

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Main Authors: Manel Ouji, Thibaud Reyser, Yoshiki Yamaryo-Botté, Michel Nguyen, David Rengel, Axelle Dutreuil, Marlène Marcellin, Odile Burlet-Schiltz, Jean-Michel Augereau, Michael K. Riscoe, Lucie Paloque, Cyrille Botté, Françoise Benoit-Vical
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:International Journal for Parasitology: Drugs and Drug Resistance
Subjects:
Artemisinin resistance
Metabolism
Apicoplast
Mitochondrion
Quiescence
Online Access:http://www.sciencedirect.com/science/article/pii/S2211320724000460
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