Morphological profiling reveals neuroprotection via mitochondrial uncoupling in human dopaminergic neurons

Morphological profiling reveals neuroprotection via mitochondrial uncoupling in human dopaminergic neurons

Abstract Parkinson’s disease (PD) involves multiple pathological processes in midbrain dopaminergic (mDA) neurons, including protein degradation defects, vesicular trafficking disruption, endolysosomal dysfunction, mitochondrial issues, and oxidative stress. Current PD models often lack complexity a...

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Main Authors: Vyron Gorgogietas, Amélie Weiss, Loïc Cousin, David Hoffmann, Karen Schmitt, Arnaud Ogier, Peter A. Barbuti, Bruno F. R. Santos, Ibrahim Boussaad, Annika Wittich, Andrea Zaliani, Ole Pless, Rejko Krüger, Peter Sommer, Johannes H. Wilbertz
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-14735-0
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https://doi.org/10.1038/s41598-025-14735-0

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