DA.Vra1-congenic rats display increased gene expression and Schwann cell apoptosis but unaffected nerve regeneration compared to parental DA rats after sciatic nerve injury and repair

DA.Vra1-congenic rats display increased gene expression and Schwann cell apoptosis but unaffected nerve regeneration compared to parental DA rats after sciatic nerve injury and repair

IntroductionThe rat Vra1 locus, containing glutathione S-transferase alpha 4 (Gsta4), regulates the degeneration of central nervous system (CNS) neurons in toxin-, protein-, and injury-based models. We hypothesize that Piebald Virol Glaxo.1AV1 (PVG) alleles in Vra1 confer protection and increased ax...

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Bibliographic Details
Main Authors: Lena Stenberg, Michael Jewett, Alfredo Dueñas Rey, Maria Swanberg, Lars B. Dahlin
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
nerve injury
nerve regeneration
ATF3
cleaved caspase 3
c-Jun
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1536347/full
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https://www.frontiersin.org/articles/10.3389/fcell.2025.1536347/full

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