Validating a clinical laboratory parameter-based deisolation algorithm for patients with COVID-19 in the intensive care unit using viability PCR: the CoLaIC multicentre cohort study protocol

Validating a clinical laboratory parameter-based deisolation algorithm for patients with COVID-19 in the intensive care unit using viability PCR: the CoLaIC multicentre cohort study protocol

Introduction To investigate whether biochemical and haematological changes due to the patient’s host response (CoLab algorithm) in combination with a SARS-CoV-2 viability PCR (v-PCR) can be used to determine when a patient with COVID-19 is no longer infectious.We hypothesise that the CoLab algorithm...

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Main Authors: Albert Wolthuis, Petra F G Wolffs, Tim Frenzel, Mathie P G Leers, Frank van Rosmalen, Steven JR Meex, Otto Bekers, Bas C T van Bussel, Inge H M van Loo, Guy JM Mostard, Rémy LM Mostard, Arjen-Kars Boer, Ruben Deneer, Tom Schoenmakers, Stefan H M Gorissen, Wilhelmine P H G Verboeket-van de Venne, Walter N K A van Mook, Stephanie MC Ament, M Sesmu Arbous, Miranda van Berkel, Dirck W van Dam, William PTM van Doorn, Tom P Dormans, Silvia MAA Evers, Judith Gillis, Iwan CC van der Horst, W Nadia H Koek, Kitty CFM Linssen, Luuk C Otterspoor, Natal AW van Riel, Frans Stals
Format: Article
Language:English
Published: BMJ Publishing Group 2023-02-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/13/2/e069455.full
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