Pharmacological inhibition of SUMOylation with TAK-981 mimics genetic HypoSUMOylation in murine perigonadal white adipose tissue

Pharmacological inhibition of SUMOylation with TAK-981 mimics genetic HypoSUMOylation in murine perigonadal white adipose tissue

Post-translational modification by the small ubiquitin-like modifier (SUMO) is essential for cellular differentiation and homeostasis. Here, we investigate the role of SUMOylation in adipose tissue development using TAK-981, a pharmacological inhibitor of SUMOylation. Administration of TAK-981 to mi...

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Bibliographic Details
Main Authors: Damien Dufour, Xu Zhao, Florian Chaleil, Patrizia Maria Christiane Nothnagel, Magnar Bjørås, Anne-Marie Lefrançois-Martinez, Antoine Martinez, Pierre Chymkowitch
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Adipocyte
Subjects:
SUMOylation
adipose tissue
adipogenesis
inflammation
TAK-981
Online Access:https://www.tandfonline.com/doi/10.1080/21623945.2025.2474107
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https://www.tandfonline.com/doi/10.1080/21623945.2025.2474107

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