Effects of the number of ethylene glycol units on the efficacy of novel complex I inhibitor 9bw

Effects of the number of ethylene glycol units on the efficacy of novel complex I inhibitor 9bw

4′-Iodobiphenyl nonaethylene glycol ether (9bw) is a novel small molecule, composed of a biphenyl unit and 9 ethylene glycol (EG) units. Recently, we found that 9bw induces apoptosis in cancer cells by inhibiting mitochondrial respiratory complex I (CI) and accordingly reducing cellular ATP level. I...

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Main Authors: Kazuaki Sekimoto, Hanaka Kinjo, Mizuki Murakami, Akiko Ohashi, Rei Fukui, Eri Nagasaki-Maeoka, Yoshinori Inagaki, Tadateru Takayama, Kazuhiro Ikeda, Ken-ichi Takayama, Satoshi Inoue, Motonori Tsuji, Joe Otsuki, Kyoko Fujiwara
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Biochemistry and Biophysics Reports
Subjects:
Respiratory complex I
9bw
4′-iodobiphenyl
Ethylene glycol
Oral squamous cell carcinoma
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580825000688
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