Regulatory T cells define affinity thresholds for CD8+ T cell tumor infiltration

Regulatory T cells define affinity thresholds for CD8+ T cell tumor infiltration

Abstract TCR repertoires against tumors lack high-affinity TCRs and are further suppressed by Tregs. We hypothesized that Treg depletion enhances the antitumor efficacy of low-affinity T cells. Using the weak agonistic peptide A4Y derived from LCMV glycoprotein peptide p33 as a model antigen and VLP...

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Main Authors: Mona O. Mohsen, Romano Josi, Sanjana V. Marar, Anish Ghimire, Lan Yang, Pascal S. Krenger, Arnau Solé Casaramona, Daniel E. Speiser, Simone De Brot, Martin F. Bachmann
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-025-01177-y
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https://doi.org/10.1038/s41541-025-01177-y

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