Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer’s disease through disrupted regulated intramembrane proteolysis

Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer’s disease through disrupted regulated intramembrane proteolysis

Abstract Background Mutations in PSEN1 cause familial Alzheimer’s disease with almost complete penetrance. Age at onset is highly variable between different PSEN1 mutations and even within families with the same mutation. Current research into late onset Alzheimer’s disease implicates inflammation i...

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Main Authors: Oliver J. Ziff, Gustavo Morrone Parfitt, Sarah Jolly, Jackie M. Casey, Lucy Granat, Satinder Samra, Núria Setó-Salvia, Argyro Alatza, Leela Phadke, Benjamin Galet, Philippe Ravassard, Marie-Claude Potier, John Hardy, Dervis A. Salih, Paul Whiting, Fiona Ducotterd, Rickie Patani, Selina Wray, Charles Arber
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Molecular Neurodegeneration
Subjects:
iPSC
Astrocyte
PSEN1
Alzheimer’s disease
Inflammation
Regulated intramembrane proteolysis
Online Access:https://doi.org/10.1186/s13024-025-00864-7
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https://doi.org/10.1186/s13024-025-00864-7

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