Patient-specific therapeutic benefit of MuSK agonist antibody ARGX-119 in MuSK myasthenia gravis passive transfer models

Patient-specific therapeutic benefit of MuSK agonist antibody ARGX-119 in MuSK myasthenia gravis passive transfer models

Summary: Muscle-specific kinase (MuSK) orchestrates the establishment and maintenance of neuromuscular synapses. Autoantibodies targeting MuSK cause myasthenia gravis (MG), a disease characterized by skeletal muscle weakness. MuSK autoantibodies are predominantly IgG4 which are bispecific, functiona...

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Main Authors: Jamie L. Lim, Stine Marie Jensen, Jaap J. Plomp, Bernhardt Vankerckhoven, Christa Kneip, Rani Coppejans, Christophe Steyaert, Kathleen Moens, Lieselot De Clercq, Martijn R. Tannemaat, Peter Ulrichts, Karen Silence, Silvère M. van der Maarel, Dana L.E. Vergoossen, Roeland Vanhauwaert, Jan J. Verschuuren, Maartje G. Huijbers
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:iScience
Subjects:
Health sciences
Medicine
Medical specialty
Immunology
Natural sciences
Biological sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224029110
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http://www.sciencedirect.com/science/article/pii/S2589004224029110

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