Enhancing the Drug Release and Physicochemical Properties of Rivaroxaban via Cyclodextrin Complexation: A Comprehensive Analytical Approach

Enhancing the Drug Release and Physicochemical Properties of Rivaroxaban via Cyclodextrin Complexation: A Comprehensive Analytical Approach

<b>Background/Objectives</b>: Rivaroxaban, an oral anticoagulant, shows poor aqueous solubility, posing significant challenges to its bioavailability and therapeutic efficiency. The present study investigates the improvement of rivaroxaban’s solubility through the formation of different...

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Main Authors: Cristina Solomon, Valentina Anuța, Iulian Sarbu, Emma Adriana Ozon, Adina Magdalena Musuc, Veronica Bratan, Adriana Rusu, Vasile-Adrian Surdu, Cătălin Croitoru, Abhay Chandak, Roxana Mariuca Gavriloaia, Teodora Dalila Balaci, Denisa Teodora Niță, Mirela Adriana Mitu
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Pharmaceuticals
Subjects:
rivaroxaban
β-cyclodextrin
methyl-β-cyclodextrin
hydroxypropyl-β-cyclodextrin
solubility enhancement
pharmaceutical formulation
Online Access:https://www.mdpi.com/1424-8247/18/6/761
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