Factor XI localization in human deep venous thrombus and function of activated factor XI on venous thrombus formation and hemostasis

Factor XI localization in human deep venous thrombus and function of activated factor XI on venous thrombus formation and hemostasis

Background: Novel anticoagulants targeting coagulation factor (F)XI/activated FXI (FXIa) are currently under development. However, whether FXI is present in human deep vein thrombosis (DVT) and whether FXIa and activated FX (FXa) play different roles in venous thrombus formation and hemostasis remai...

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Main Authors: Nobuyuki Oguri, Toshihiro Gi, Eriko Nakamura, Kazunari Maekawa, Eiji Furukoji, Hoshimi Okawa, Sho Kouyama, Saki Horiuchi, Akira Sawaguchi, Tatefumi Sakae, Minako Azuma, Yujiro Asada, Atsushi Yamashita
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Research and Practice in Thrombosis and Haemostasis
Subjects:
factor X
factor XI
hemostasis
pathology
venous thromboembolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2475037925000445
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